HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: RB40C (Q96S21)
Ras-related protein Rab-40C (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3)
Gene: RAB40C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.954

Property	Details
Experiments	28514442, 31253590, 33961781, 21145461, 35512830, 15601820
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 780 Hs			1 281
+	Hs
		1017277 CUL5_HUMAN (1-780): 0: 792: 100.00		RB40B_HUMAN (1-281): 7.92e-101: 297: 78.65
+	Hs
		469822 CUL5_HUMAN (1-780): 0: 792: 100.00		RB40L_HUMAN (1-281): 3.27e-97: 288: 73.67
+	Hs
		1263839 CUL5_HUMAN (1-780): 0: 792: 100.00		RB40A_HUMAN (1-281): 7.41e-97: 287: 74.02
+	Xl
		64998 A7VK04_XENLA (1-780): 0: 793: 98.33		Q5XHF6_XENLA (1-281): 4.69e-95: 283: 92.66
+	Mm
		1257622 CUL5_MOUSE (1-780): 0: 786: 98.46		RB40C_MOUSE (1-281): 3.03e-96: 286: 99.29
+	Hs
		895481 CUL3_HUMAN (8-780): 0: 754: 22.96		RAB10_HUMAN (9-197): 1.9e-95: 280: 40.61
+	Hs
		845850 CUL3_HUMAN (8-780): 0: 754: 22.96		RAB13_HUMAN (7-197): 7.11e-91: 269: 41.15
+	Hs
		1042510 CUL3_HUMAN (8-780): 0: 754: 22.96		RAB1B_HUMAN (7-197): 6.3e-85: 254: 36.32
+	Hs
		1043210 CUL4A_HUMAN (16-780): 0: 744: 24.48		RAB1B_HUMAN (7-197): 6.3e-85: 254: 36.32
+	Hs
		886518 CUL3_HUMAN (8-780): 0: 754: 22.96		RAB15_HUMAN (9-181): 4.62e-46: 155: 44.25