HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: CSN8 (Q99627)
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)
Gene: COPS8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	30587576, 31253590, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 780 Hs			1 209
+	Hs
		1042368 CUL3_HUMAN (8-780): 0: 754: 22.96		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1041162 CUL1_HUMAN (11-780): 0: 748: 27.84		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1043183 CUL4A_HUMAN (16-780): 0: 744: 24.48		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1043536 CUL4B_HUMAN (16-780): 0: 736: 25.39		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	Hs
		1041445 CUL2_HUMAN (6-780): 0: 699: 26.36		CSN8_HUMAN (1-209): 4.26e-116: 330: 100.00
+	At
		794521 CUL3A_ARATH (16-780): 0: 759: 23.18		CSN8_ARATH (7-209): 9.28e-80: 238: 31.40
+	At
		794514 CUL4_ARATH (16-780): 0: 694: 24.09		CSN8_ARATH (7-209): 9.28e-80: 238: 31.40