HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: DCNL5 (Q9BTE7)
DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
Gene: DCUN1D5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	31253590, 23201271, 26906416
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin_Nedd8~Cullin_binding
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 237
+	Hs
		1267355 CUL5_HUMAN (1-780): 0: 792: 100.00		DCNL4_HUMAN (1-237): 7.42e-108: 314: 69.62
+	Hs
		1042423 CUL3_HUMAN (8-780): 0: 754: 22.96		DCNL5_HUMAN (1-237): 5.44e-117: 335: 100.00
+	Hs
		1041180 CUL1_HUMAN (11-780): 0: 748: 27.84		DCNL5_HUMAN (1-237): 5.44e-117: 335: 100.00
+	Hs
		1043197 CUL4A_HUMAN (16-780): 0: 744: 24.48		DCNL5_HUMAN (1-237): 5.44e-117: 335: 100.00
+	Hs
		1161494 CUL5_HUMAN (1-780): 0: 792: 100.00		DCNL2_HUMAN (28-232): 2.9e-97: 286: 32.85
+	Hs
		1218597 CUL5_HUMAN (1-780): 0: 792: 100.00		DCNL3_HUMAN (12-235): 1.71e-93: 278: 28.70
+	Hs
		1042176 CUL3_HUMAN (8-780): 0: 754: 22.96		DCNL4_HUMAN (1-237): 7.42e-108: 314: 69.62
+	Hs
		1274016 CUL5_HUMAN (1-780): 0: 792: 100.00		DCNL1_HUMAN (28-234): 1.17e-93: 276: 31.58
+	Hs
		1041123 CUL1_HUMAN (11-780): 0: 748: 27.84		DCNL4_HUMAN (1-237): 7.42e-108: 314: 69.62
+	Hs
		1043133 CUL4A_HUMAN (16-780): 0: 744: 24.48		DCNL4_HUMAN (1-237): 7.42e-108: 314: 69.62
+	Hs
		1041837 CUL3_HUMAN (8-780): 0: 754: 22.96		DCNL2_HUMAN (28-232): 2.9e-97: 286: 32.85
+	Hs
		1041051 CUL1_HUMAN (11-780): 0: 748: 27.84		DCNL2_HUMAN (28-232): 2.9e-97: 286: 32.85
+	Hs
		1041979 CUL3_HUMAN (8-780): 0: 754: 22.96		DCNL3_HUMAN (12-235): 1.71e-93: 278: 28.70
+	Hs
		1042270 CUL3_HUMAN (8-780): 0: 754: 22.96		DCNL1_HUMAN (28-234): 1.17e-93: 276: 31.58
+	Hs
		1043062 CUL4A_HUMAN (16-780): 0: 744: 24.48		DCNL2_HUMAN (28-232): 2.9e-97: 286: 32.85
+	Hs
		1041081 CUL1_HUMAN (11-780): 0: 748: 27.84		DCNL3_HUMAN (12-235): 1.71e-93: 278: 28.70
+	Hs
		1041145 CUL1_HUMAN (11-780): 0: 748: 27.84		DCNL1_HUMAN (28-234): 1.17e-93: 276: 31.58
+	Hs
		1043091 CUL4A_HUMAN (16-780): 0: 744: 24.48		DCNL3_HUMAN (12-235): 1.71e-93: 278: 28.70
+	Hs
		1043412 CUL4B_HUMAN (16-780): 0: 736: 25.39		DCNL2_HUMAN (28-232): 2.9e-97: 286: 32.85
+	Hs
		1043159 CUL4A_HUMAN (16-780): 0: 744: 24.48		DCNL1_HUMAN (28-234): 1.17e-93: 276: 31.58