HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.943

Property	Details
Experiments	31253590, 26186194, 28514442, 33961781, 16961462, 18508766
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 258
+	Mm
		1143676 CUL5_MOUSE (1-780): 0: 786: 98.46		CISH_MOUSE (1-258): 3.74e-69: 215: 90.31
+	Hs
		146642 CUL5_HUMAN (1-780): 0: 792: 100.00		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Mm
		193366 CUL5_MOUSE (1-780): 0: 786: 98.46		SOCS2_MOUSE (45-258): 2.45e-52: 170: 35.98
+	Hs
		147440 CUL5_HUMAN (1-780): 0: 792: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		147544 CUL5_HUMAN (1-780): 0: 792: 100.00		SOCS6_HUMAN (46-256): 4.63e-45: 160: 25.69
+	Hs
		146692 CUL5_HUMAN (1-780): 0: 792: 100.00		SOCS7_HUMAN (43-256): 3.74e-43: 155: 25.93
+	Hs
		1263831 CUL5_HUMAN (1-780): 0: 792: 100.00		SOCS4_HUMAN (47-257): 2.54e-42: 151: 25.35
+	Mm
		1257617 CUL5_MOUSE (1-780): 0: 786: 98.46		SOCS7_MOUSE (43-256): 1.71e-43: 156: 25.46
+	Mm
		1322060 CUL5_MOUSE (1-780): 0: 786: 98.46		SOCS6_MOUSE (46-256): 1.46e-43: 156: 26.15
+	Hs
		256856 CUL5_HUMAN (1-780): 0: 792: 100.00		SOCS5_HUMAN (59-257): 3.09e-41: 149: 25.87
+	Mm
		1265273 CUL5_MOUSE (1-780): 0: 786: 98.46		SOCS4_MOUSE (43-257): 1.88e-42: 151: 25.35
+	Hs
		181885 CUL5_HUMAN (1-780): 0: 792: 100.00		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Mm
		222648 CUL5_MOUSE (1-780): 0: 786: 98.46		SOCS5_MOUSE (59-257): 1.8e-40: 148: 25.87
+	Mm
		193357 CUL5_MOUSE (1-780): 0: 786: 98.46		SOCS1_MOUSE (55-258): 2.79e-41: 142: 28.16
+	Mm
		193394 CUL5_MOUSE (1-780): 0: 786: 98.46		SOCS3_MOUSE (43-254): 1.24e-40: 141: 29.77
+	Hs
		146625 CUL4A_HUMAN (16-780): 0: 744: 24.48		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		411713 CUL3_HUMAN (8-780): 0: 754: 22.96		LCK_HUMAN (44-196): 2.13e-39: 144: 17.39
+	Hs
		655358 CUL3_HUMAN (8-780): 0: 754: 22.96		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		129293 CUL3_HUMAN (8-780): 0: 754: 22.96		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42
+	Hs
		1028467 CUL4A_HUMAN (16-780): 0: 744: 24.48		SLAP1_HUMAN (30-209): 1.05e-19: 87.7: 17.23