HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: APC11 (Q9NYG5)
Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) (Hepatocellular carcinoma-associated RING finger protein)
Gene: ANAPC11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	31253590, 10230407
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cullin~zf-ANAPC11
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 84
+	Hs
		921374 CUL5_HUMAN (1-780): 0: 792: 100.00		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Hs
		1274072 CUL5_HUMAN (1-780): 0: 792: 100.00		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	At
		1275966 CUL3A_ARATH (16-780): 0: 759: 23.18		RBX1A_ARATH (2-84): 3.26e-28: 99.8: 37.50
+	Hs
		921253 CUL3_HUMAN (8-780): 0: 754: 22.96		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Hs
		921251 CUL1_HUMAN (11-780): 0: 748: 27.84		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Mm
		921509 CUL1_MOUSE (11-780): 0: 748: 27.84		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Mm
		921499 CUL4A_MOUSE (16-780): 0: 745: 24.48		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Hs
		921254 CUL4A_HUMAN (16-780): 0: 744: 24.48		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	At
		1275962 CUL3B_ARATH (16-780): 0: 744: 23.18		RBX1A_ARATH (2-84): 3.26e-28: 99.8: 37.50
+	Hs
		1042735 CUL3_HUMAN (8-780): 0: 754: 22.96		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Mm
		56790 CUL4B_MOUSE (16-780): 0: 736: 25.26		RBX1_MOUSE (2-84): 6.06e-29: 101: 37.50
+	Hs
		921255 CUL4B_HUMAN (16-780): 0: 736: 25.39		RBX1_HUMAN (2-84): 6.06e-29: 101: 37.50
+	Dm
		1213855 Q8IP45_DROME (5-780): 0: 736: 22.73		RBX1A_DROME (2-84): 1.22e-28: 100: 37.50
+	Hs
		1041242 CUL1_HUMAN (11-780): 0: 748: 27.84		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Dm
		1213836 Q8IP45_DROME (5-780): 0: 736: 22.73		RBX1B_DROME (2-84): 3.25e-26: 94.8: 34.48
+	Mm
		1111822 CUL4A_MOUSE (16-780): 0: 745: 24.48		RBX2_MOUSE (3-84): 1.19e-22: 85.5: 34.52
+	Hs
		1043275 CUL4A_HUMAN (16-780): 0: 744: 24.48		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	Hs
		1043627 CUL4B_HUMAN (16-780): 0: 736: 25.39		RBX2_HUMAN (3-84): 1.1e-22: 85.5: 34.52
+	At
		1275960 CUL1_ARATH (8-780): 0: 721: 24.34		RBX1A_ARATH (2-84): 3.26e-28: 99.8: 37.50
+	Hs
		296909 CUL3_HUMAN (8-780): 0: 754: 22.96		LTN1_HUMAN (18-80): 6.02e-13: 63.9: 23.81