HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: KLH42 (Q9P2K6)
Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5)
Gene: KLHL42

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 505
+	Hs
		299529 CUL5_HUMAN (1-780): 0: 792: 100.00		KLH18_HUMAN (2-498): 3.63e-100: 314: 17.40
+	Hs
		1041715 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH22_HUMAN (6-501): 8.93e-110: 341: 19.21
+	Hs
		1042027 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH36_HUMAN (6-504): 5.8e-108: 335: 20.84
+	Hs
		1041547 CUL3_HUMAN (8-780): 0: 754: 22.96		KEAP1_HUMAN (4-504): 6.64e-101: 317: 15.75
+	Mm
		1337550 CUL3_MOUSE (8-780): 0: 754: 22.96		KEAP1_MOUSE (4-504): 1.96e-99: 314: 16.46
+	Hs
		299515 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH18_HUMAN (2-498): 3.63e-100: 314: 17.40
+	Rn
		78189 CUL3_RAT (8-780): 0: 755: 22.96		KLH17_RAT (2-499): 1.13e-92: 296: 16.37
+	Hs
		1041852 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH17_HUMAN (2-499): 2.6e-92: 296: 16.02
+	Hs
		1041718 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH26_HUMAN (4-504): 1.01e-88: 285: 19.30
+	Hs
		1041853 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH24_HUMAN (3-503): 6.17e-88: 283: 16.70
+	Hs
		1041712 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH12_HUMAN (56-450): 1.45e-54: 194: 13.03
+	Hs
		1042057 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH23_HUMAN (171-392): 6.43e-35: 139: 23.89
+	Hs
		1041807 CUL3_HUMAN (8-780): 0: 754: 22.96		KLH10_HUMAN (329-498): 3.32e-26: 114: 14.04
+	Mm
		1322059 CUL3_MOUSE (8-780): 0: 754: 22.96		KLH10_MOUSE (329-498): 1.47e-25: 112: 14.04
+	Mm
		1225041 CUL3_MOUSE (8-780): 0: 754: 22.96		KLHL2_MOUSE (172-346): 9.57e-23: 103: 23.33
+	Hs
		307170 CUL3_HUMAN (8-780): 0: 754: 22.96		KLHL2_HUMAN (172-346): 7.92e-23: 103: 23.89
+	Hs
		1042083 CUL3_HUMAN (8-780): 0: 754: 22.96		KBTB8_HUMAN (142-479): 1.17e-20: 97.4: 26.36
+	Hs
		296838 CUL3_HUMAN (8-780): 0: 754: 22.96		KBTBB_HUMAN (351-487): 4.5e-11: 67.1: 13.67
+	Hs
		87524 CUL3_HUMAN (8-780): 0: 754: 22.96		KBTBD_HUMAN (362-495): 4.15e-11: 67.1: 13.67
+	Hs
		1042167 CUL3_HUMAN (8-780): 0: 754: 22.96		KLHL6_HUMAN (238-377): 9.69e-09: 59.7: 26.06