HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: RBX2 (Q9UBF6)
RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)
Gene: RNF7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 25216516, 19250909, 23333304, 25912140, 24438103, 10230407, 27910872, 27591266, 29958295, 32296183, 32145688, 33961781, 34518685, 35982156, 36253371, 17828303, 25416956, 21516116, 25505247, 28514442 and 6 others

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Identification Methods affinity chromatography technology, enzymatic study, pull down, biochemical, two hybrid, x-ray crystallography, validated two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0031466 - Cul5-RING ubiquitin ligase complex
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 780
Hs

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Last updated: 15 Jul 2024