HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: WSB1 (Q9Y6I7)
WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)
Gene: WSB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	18187417, 28514442, 31253590, 33961781, 21145461, 15601820
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 421
+	Hs
		1043340 CUL4A_HUMAN (16-780): 0: 744: 24.48		WSB1_HUMAN (1-421): 1.22e-100: 307: 100.00
+	Hs
		792982 CUL4A_HUMAN (16-780): 0: 744: 24.48		LIS1_HUMAN (2-286): 2.98e-83: 262: 20.72
+	Mm
		1257398 CUL1_MOUSE (11-780): 0: 748: 27.84		FBXW7_MOUSE (2-334): 6.45e-76: 251: 19.05
+	Hs
		1041133 CUL1_HUMAN (11-780): 0: 748: 27.84		FBXW7_HUMAN (2-334): 4.09e-75: 249: 19.05
+	Hs
		1043157 CUL4A_HUMAN (16-780): 0: 744: 24.48		SNR40_HUMAN (2-282): 1.31e-65: 215: 20.42
+	Hs
		1042101 CUL3_HUMAN (8-780): 0: 754: 22.96		POC1B_HUMAN (205-421): 5.6e-60: 204: 21.17
+	Hs
		1043114 CUL4A_HUMAN (16-780): 0: 744: 24.48		POC1B_HUMAN (205-421): 5.6e-60: 204: 21.17
+	Hs
		1274067 CUL5_HUMAN (1-780): 0: 792: 100.00		WSB2_HUMAN (2-198): 1.18e-28: 117: 15.50
+	Hs
		1041647 CUL3_HUMAN (8-780): 0: 754: 22.96		TAF5_HUMAN (206-382): 7.7e-36: 142: 20.08
+	Hs
		863424 CUL3_HUMAN (8-780): 0: 754: 22.96		COPA_HUMAN (206-381): 7.82e-34: 136: 18.54
+	Hs
		863425 CUL4A_HUMAN (16-780): 0: 744: 24.48		COPA_HUMAN (206-381): 7.82e-34: 136: 18.54
+	Hs
		903207 CUL3_HUMAN (8-780): 0: 754: 22.96		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27
+	Hs
		1042655 CUL3_HUMAN (8-780): 0: 754: 22.96		NLE1_HUMAN (298-418): 5.4e-28: 117: 18.94
+	Hs
		903206 CUL1_HUMAN (11-780): 0: 748: 27.84		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27
+	Hs
		903208 CUL4A_HUMAN (16-780): 0: 744: 24.48		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27
+	Hs
		1043262 CUL4A_HUMAN (16-780): 0: 744: 24.48		WSB2_HUMAN (2-198): 1.18e-28: 117: 15.50
+	Hs
		903209 CUL4B_HUMAN (16-780): 0: 736: 25.39		WDR5_HUMAN (295-420): 1.65e-30: 121: 15.27
+	Hs
		1043085 CUL4A_HUMAN (16-780): 0: 744: 24.48		WDR5B_HUMAN (285-420): 5.67e-27: 111: 13.48
+	Hs
		1043441 CUL4B_HUMAN (16-780): 0: 736: 25.39		WDR5B_HUMAN (285-420): 5.67e-27: 111: 13.48
+	Hs
		245601 CUL4B_HUMAN (16-780): 0: 736: 25.39		TBL1X_HUMAN (289-418): 1.94e-18: 89.4: 13.42