HitPredict

Interactor 1: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 2177 Hs			1 456
+	Hs
		1270840 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Mm
		888094 EP400_MOUSE (1822-2169): 6.65e-09: 63.8: 17.18		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		1296858 EP400_HUMAN (1812-2174): 7.89e-09: 63.4: 17.63		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1296857 EP400_HUMAN (1812-2174): 7.89e-09: 63.4: 17.63		RUVB2_HUMAN (2-455): 0: 651: 42.76