HitPredict

Interactor 1: RBX1A (Q940X7)
RING-box protein 1a (At-Rbx1;1) (Protein RING of cullins 1) (RBX1-2) (RBX1a-At)
Gene: RBX1A

Interactor 2: CUL3A (Q9ZVH4)
Cullin-3A (AtCUL3a)
Gene: CUL3A

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.923

Property	Details
Experiments	15659098, 15772280, 16792691, 15749712, 15618422
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0031461 - cullin-RING ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 118 At			1 732
+	At
		1275962 RBX1A_ARATH (1-118): 1.59e-55: 170: 100.00		CUL3B_ARATH (1-732): 0: 919: 88.12
+	Hs
		921253 RBX1_HUMAN (21-118): 1.88e-47: 149: 88.78		CUL3_HUMAN (3-732): 0: 846: 51.64
+	Dm
		1213855 RBX1A_DROME (15-118): 1.54e-48: 152: 86.54		Q8IP45_DROME (17-732): 0: 809: 48.67
+	Hs
		921254 RBX1_HUMAN (21-118): 1.88e-47: 149: 88.78		CUL4A_HUMAN (6-732): 0: 812: 38.75
+	Mm
		921499 RBX1_MOUSE (21-118): 1.88e-47: 149: 88.78		CUL4A_MOUSE (3-732): 0: 806: 38.72
+	Mm
		56790 RBX1_MOUSE (21-118): 1.88e-47: 149: 88.78		CUL4B_MOUSE (4-732): 0: 802: 39.18
+	Hs
		921255 RBX1_HUMAN (21-118): 1.88e-47: 149: 88.78		CUL4B_HUMAN (4-732): 0: 802: 39.05
+	At
		1228140 RBX1A_ARATH (1-118): 1.59e-55: 170: 100.00		CUL4_ARATH (4-732): 0: 776: 39.81
+	Dm
		1124381 RBX1A_DROME (15-118): 1.54e-48: 152: 86.54		Q5BI50_DROME (7-732): 0: 792: 40.68
+	At
		1275960 RBX1A_ARATH (1-118): 1.59e-55: 170: 100.00		CUL1_ARATH (25-732): 0: 736: 33.78
+	Hs
		921251 RBX1_HUMAN (21-118): 1.88e-47: 149: 88.78		CUL1_HUMAN (25-732): 0: 747: 30.47
+	Mm
		921509 RBX1_MOUSE (21-118): 1.88e-47: 149: 88.78		CUL1_MOUSE (25-732): 0: 747: 30.47
+	Hs
		921252 RBX1_HUMAN (21-118): 1.88e-47: 149: 88.78		CUL2_HUMAN (25-732): 0: 708: 30.21
+	Dm
		1097212 RBX1A_DROME (15-118): 1.54e-48: 152: 86.54		CUL1_DROME (24-732): 0: 702: 29.09
+	Sp
		142904 RBX1_SCHPO (13-118): 1.05e-46: 147: 73.59		CUL1_SCHPO (28-732): 0: 686: 29.99
+	Sp
		143631 RBX1_SCHPO (13-118): 1.05e-46: 147: 73.59		CUL3_SCHPO (4-732): 0: 662: 35.36
+	Ce
		1088871 RBX1_CAEEL (13-118): 1.07e-46: 147: 76.42		CUL2_CAEEL (25-732): 0: 650: 25.45
+	Dm
		1360503 RBX1A_DROME (15-118): 1.54e-48: 152: 86.54		Q9V9R2_DROME (25-732): 0: 630: 25.56
+	Hs
		921374 RBX1_HUMAN (21-118): 1.88e-47: 149: 88.78		CUL5_HUMAN (25-732): 0: 581: 23.36
+	Ce
		1095356 RBX1_CAEEL (13-118): 1.07e-46: 147: 76.42		CUL5_CAEEL (25-732): 0: 571: 24.03