HitPredict

Interactor 1: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Interactor 2: Q9VKD5 (Q9VKD5)
Escl, isoform A (Escl, isoform C) (SD11903p)
Gene: escl

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18048023
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0035098 - ESC/E(Z) complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 521 Dm			1 462
+	Hs
		1270358 HDAC2_HUMAN (2-488): 0: 659: 76.59		FBXW7_HUMAN (2-280): 4.61e-41: 157: 11.37
+	Hs
		177369 HDAC3_HUMAN (6-427): 0: 572: 56.37		TBL1Y_HUMAN (153-462): 4.47e-61: 209: 15.04
+	Hs
		903404 HDAC2_HUMAN (2-488): 0: 659: 76.59		WDR5_HUMAN (296-462): 1.73e-27: 113: 12.43
+	Dm
		1182201 Q7KTS4_DROME (5-428): 0: 556: 56.48		EBI_DROME (157-462): 2.83e-61: 213: 13.77
+	Dm
		1279322 Q9VNC2_DROME (5-428): 0: 553: 56.25		EBI_DROME (157-462): 2.83e-61: 213: 13.77
+	Hs
		245623 HDAC2_HUMAN (2-488): 0: 659: 76.59		TBL1X_HUMAN (296-459): 1.68e-20: 96.1: 14.46
+	Hs
		863507 HDAC2_HUMAN (2-488): 0: 659: 76.59		COPA_HUMAN (327-462): 1.18e-18: 91.1: 12.32
+	Hs
		903202 HDAC1_HUMAN (3-443): 0: 637: 81.18		WDR5_HUMAN (296-462): 1.73e-27: 113: 12.43
+	Dm
		1097598 HDAC1_DROME (1-521): 0: 674: 100.00		ESC_DROME (9-243): 2.99e-09: 60.7: 9.60
+	Hs
		1270370 HDAC2_HUMAN (2-488): 0: 659: 76.59		SNR40_HUMAN (357-462): 5.65e-14: 74.9: 14.15
+	Hs
		245600 HDAC1_HUMAN (3-443): 0: 637: 81.18		TBL1X_HUMAN (296-459): 1.68e-20: 96.1: 14.46
+	Hs
		268201 HDAC2_HUMAN (2-488): 0: 659: 76.59		EED_HUMAN (22-285): 6.27e-10: 63: 8.31
+	Mm
		140307 HDAC1_MOUSE (3-443): 0: 640: 81.18		EED_MOUSE (22-285): 6.27e-10: 63: 8.31
+	Hs
		268072 HDAC1_HUMAN (3-443): 0: 637: 81.18		EED_HUMAN (22-285): 6.27e-10: 63: 8.31
+	Hs
		177249 HDAC3_HUMAN (6-427): 0: 572: 56.37		WDR5_HUMAN (296-462): 1.73e-27: 113: 12.43
+	Hs
		177148 HDAC3_HUMAN (6-427): 0: 572: 56.37		TBL1X_HUMAN (296-459): 1.68e-20: 96.1: 14.46
+	Sp
		140687 PHD1_SCHPO (5-406): 0: 519: 52.84		COPA_SCHPO (181-456): 6.83e-35: 140: 17.63
+	Mm
		1112825 HDAC4_MOUSE (5-405): 1.49e-134: 418: 23.83		SMU1_MOUSE (3-239): 8.28e-20: 93.8: 12.11
+	Hs
		245584 HDAC4_HUMAN (5-405): 2.08e-133: 415: 22.86		TBL1X_HUMAN (296-459): 1.68e-20: 96.1: 14.46
+	Mm
		1157751 HDAC4_MOUSE (5-405): 1.49e-134: 418: 23.83		COPA_MOUSE (327-462): 1.63e-18: 90.7: 12.32