HitPredict

Interactor 1: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Interactor 2: KDM5 (Q9VMJ7)
Lysine-specific demethylase 5 (EC 1.14.11.67) (Histone demethylase lid) (Jumonji/ARID domain-containing protein lid) (Protein little imaginal disks) (lid) (Retinoblastoma-binding protein 2 homolog) ([histone H3]-trimethyl-L-lysine(4) demethylase Kdm5)
Gene: KDM5

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	19114561, 26848313, 19782028
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0006355 - regulation of DNA-templated transcription GO:0070822 - Sin3-type complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 521 Dm			1 1838
+	Hs
		666546 HDAC2_HUMAN (2-488): 0: 659: 76.59		KDM5A_HUMAN (149-1807): 0: 938: 38.12
+	Hs
		666529 HDAC1_HUMAN (3-443): 0: 637: 81.18		KDM5A_HUMAN (149-1807): 0: 938: 38.12
+	Hs
		782369 HDAC2_HUMAN (2-488): 0: 659: 76.59		KDM5C_HUMAN (150-1652): 0: 903: 39.87
+	Hs
		782341 HDAC1_HUMAN (3-443): 0: 637: 81.18		KDM5C_HUMAN (150-1652): 0: 903: 39.87
+	Hs
		1270349 HDAC2_HUMAN (2-488): 0: 659: 76.59		JARD2_HUMAN (1-462): 3.52e-102: 360: 21.60
+	Hs
		528410 HDAC1_HUMAN (3-443): 0: 637: 81.18		MYH8_HUMAN (728-1556): 5.57e-95: 344: 12.43
+	Hs
		1038707 HDAC1_HUMAN (3-443): 0: 637: 81.18		KDM4C_HUMAN (474-1150): 2.93e-95: 336: 18.48
+	Hs
		256969 HDAC1_HUMAN (3-443): 0: 637: 81.18		KDM4A_HUMAN (474-1374): 8.35e-92: 325: 16.86
+	Hs
		177381 HDAC3_HUMAN (6-427): 0: 572: 56.37		KDM4C_HUMAN (474-1150): 2.93e-95: 336: 18.48
+	Hs
		177151 HDAC3_HUMAN (6-427): 0: 572: 56.37		KDM4A_HUMAN (474-1374): 8.35e-92: 325: 16.86
+	Hs
		1270501 HDAC2_HUMAN (2-488): 0: 659: 76.59		KDM5B_HUMAN (1098-1806): 7.14e-33: 142: 12.82
+	Mm
		140293 HDAC1_MOUSE (3-443): 0: 640: 81.18		KDM5B_MOUSE (1098-1806): 5.82e-33: 142: 13.65
+	Hs
		1038782 HDAC1_HUMAN (3-443): 0: 637: 81.18		KDM5B_HUMAN (1098-1806): 7.14e-33: 142: 12.82
+	Hs
		1038853 HDAC1_HUMAN (3-443): 0: 637: 81.18		MYH4_HUMAN (854-1566): 7.66e-24: 112: 10.80
+	Hs
		522547 HDAC1_HUMAN (3-443): 0: 637: 81.18		MYH1_HUMAN (840-1566): 8.25e-23: 109: 10.89
+	Hs
		1038808 HDAC1_HUMAN (3-443): 0: 637: 81.18		MYH2_HUMAN (854-1566): 1.57e-22: 108: 11.86
+	Sc
		693059 RPD3_YEAST (4-419): 0: 573: 59.81		ECM5_YEAST (105-386): 4e-41: 169: 18.90
+	Hs
		880842 HDAC4_HUMAN (5-405): 2.08e-133: 415: 22.86		KDM5B_HUMAN (1098-1806): 7.14e-33: 142: 12.82