HitPredict

Interactor 1: LHX4 (Q969G2)
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)
Gene: LHX4

Interactor 2: SSBP3 (Q9BWW4)
Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein)
Gene: SSBP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	24981860, 33961781, 35140242, 30833792
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 388
+	Hs
		1281178 LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00		SSBP4_HUMAN (5-388): 9.47e-57: 192: 69.25
+	Hs
		1314910 LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25		SSBP3_HUMAN (1-388): 5.14e-67: 218: 100.00
+	Hs
		946655 LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00		SSBP2_HUMAN (3-388): 2.7e-44: 158: 77.26
+	Hs
		1314659 LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25		SSBP4_HUMAN (5-388): 9.47e-57: 192: 69.25
+	Hs
		1281194 LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00		CHD7_HUMAN (99-332): 1.72e-32: 131: 17.60
+	Hs
		946671 LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25		SSBP2_HUMAN (3-388): 2.7e-44: 158: 77.26
+	Hs
		238119 LMX1B_HUMAN (10-347): 2.11e-62: 207: 28.00		SSBP3_HUMAN (1-388): 5.14e-67: 218: 100.00
+	Hs
		822674 LHX1_HUMAN (29-389): 3.38e-61: 204: 32.13		SSBP3_HUMAN (1-388): 5.14e-67: 218: 100.00
+	Mm
		292011 LMX1B_MOUSE (10-347): 3.61e-60: 201: 28.27		SSBP3_MOUSE (1-388): 5.14e-67: 218: 100.00
+	Hs
		1350240 LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25		CHD7_HUMAN (99-332): 1.72e-32: 131: 17.60
+	Hs
		238118 LMX1B_HUMAN (10-347): 2.11e-62: 207: 28.00		SSBP4_HUMAN (5-388): 9.47e-57: 192: 69.25
+	Hs
		822672 LHX1_HUMAN (29-389): 3.38e-61: 204: 32.13		SSBP4_HUMAN (5-388): 9.47e-57: 192: 69.25
+	Mm
		1321889 LMX1A_MOUSE (2-347): 1.01e-67: 220: 27.37		SSBP2_MOUSE (3-388): 9.79e-45: 159: 77.00
+	Mm
		291998 LMX1B_MOUSE (10-347): 3.61e-60: 201: 28.27		Q3U4B1_MOUSE (1-388): 1.81e-48: 169: 62.66
+	Hs
		238106 LMX1B_HUMAN (10-347): 2.11e-62: 207: 28.00		SSBP2_HUMAN (3-388): 2.7e-44: 158: 77.26
+	Hs
		822624 LHX1_HUMAN (29-389): 3.38e-61: 204: 32.13		SSBP2_HUMAN (3-388): 2.7e-44: 158: 77.26
+	Mm
		292010 LMX1B_MOUSE (10-347): 3.61e-60: 201: 28.27		SSBP2_MOUSE (3-388): 9.79e-45: 159: 77.00
+	Dm
		112549 M9NCY1_DROME (26-384): 5.18e-69: 224: 49.59		Q9VEB9_DROME (1-297): 1.64e-34: 134: 51.55
+	Hs
		822688 LHX1_HUMAN (29-389): 3.38e-61: 204: 32.13		CHD7_HUMAN (99-332): 1.72e-32: 131: 17.60
+	Mm
		899943 ISL1_MOUSE (20-321): 6.12e-51: 175: 27.57		SSBP2_MOUSE (3-388): 9.79e-45: 159: 77.00