HitPredict

Interactor 1: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Interactor 2: HIPK2 (Q9H2X6)
Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)
Gene: HIPK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18765672
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 707 Hs			1 1198
+	Hs
		324857 FBXW7_HUMAN (1-707): 0: 571: 100.00		M4K4_HUMAN (178-1175): 7.82e-125: 416: 12.87
+	Hs
		1329784 FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09		HIPK2_HUMAN (1-1198): 0: 885: 100.00
+	Hs
		681967 FBXW7_HUMAN (1-707): 0: 571: 100.00		AKT1_HUMAN (30-516): 1.3e-121: 386: 16.27
+	Hs
		1268574 FBXW7_HUMAN (1-707): 0: 571: 100.00		DYRK2_HUMAN (160-606): 2.42e-117: 379: 31.04
+	Hs
		415016 FBXW7_HUMAN (1-707): 0: 571: 100.00		CDK1_HUMAN (196-530): 5.99e-119: 372: 24.27
+	Hs
		625543 FBXW7_HUMAN (1-707): 0: 571: 100.00		CDK2_HUMAN (196-470): 1.65e-116: 365: 25.16
+	Hs
		1044022 FBXW7_HUMAN (1-707): 0: 571: 100.00		DYR1A_HUMAN (197-530): 6.34e-56: 210: 39.30
+	Hs
		793038 LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08		TNIK_HUMAN (178-1175): 1.08e-143: 470: 11.35
+	Mm
		949357 TBL1R_MOUSE (251-570): 8.68e-66: 228: 18.58		TNIK_MOUSE (178-1175): 7.95e-142: 464: 11.89
+	Hs
		414806 LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08		CDK1_HUMAN (196-530): 5.99e-119: 372: 24.27
+	Hs
		625202 LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08		CDK2_HUMAN (196-470): 1.65e-116: 365: 25.16
+	Dm
		1363665 Q9VDE3_DROME (607-705): 1.89e-12: 72.4: 22.00		Q9W0Q1_DROME (81-917): 1.53e-131: 437: 44.14
+	Hs
		903402 WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02		DYRK2_HUMAN (160-606): 2.42e-117: 379: 31.04
+	Hs
		129069 FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09		PLK4_HUMAN (194-1163): 1.15e-122: 404: 12.76
+	Hs
		129064 FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00		PLK4_HUMAN (194-1163): 1.15e-122: 404: 12.76
+	Hs
		682082 FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09		AKT1_HUMAN (30-516): 1.3e-121: 386: 16.27
+	Hs
		415113 FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09		CDK1_HUMAN (196-530): 5.99e-119: 372: 24.27
+	Hs
		1044128 TBL1R_HUMAN (251-570): 8.42e-66: 228: 18.58		DYR1A_HUMAN (197-530): 6.34e-56: 210: 39.30
+	Hs
		1044288 FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09		DYR1A_HUMAN (197-530): 6.34e-56: 210: 39.30
+	Ce
		1000139 LIN23_CAEEL (614-705): 1.75e-10: 66.2: 22.83		MBK2_CAEEL (173-527): 2.47e-50: 194: 36.11