HitPredict

Interactor 1: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Interactor 2: FBXW2 (Q9UKT8)
F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)
Gene: FBXW2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	F-box-like~F-box-like, WD40~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 707 Hs			1 454
+	Hs
		1281292 FBXW7_HUMAN (1-707): 0: 571: 100.00		FBXW7_HUMAN (32-264): 4.84e-57: 201: 21.85
+	Hs
		903418 FBXW7_HUMAN (1-707): 0: 571: 100.00		WDR5_HUMAN (353-451): 3.15e-13: 72.5: 6.93
+	Dm
		1358859 FBXW7_DROME (142-705): 3.41e-131: 421: 66.33		WDS_DROME (313-451): 1.92e-24: 105: 11.27
+	Sc
		431134 MET30_YEAST (447-706): 5.61e-59: 212: 25.24		CDC4_YEAST (19-417): 2.5e-73: 247: 17.46
+	Mm
		925836 LIS1_MOUSE (457-706): 3e-66: 226: 27.08		LIS1_MOUSE (16-256): 1.38e-52: 183: 16.18
+	Hs
		792935 LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08		LIS1_HUMAN (16-256): 1.66e-52: 183: 16.18
+	Hs
		245633 TBL1R_HUMAN (251-570): 8.42e-66: 228: 18.58		TBL1X_HUMAN (30-257): 4.63e-44: 164: 16.05
+	Sc
		431103 CDC4_YEAST (536-707): 7.01e-30: 128: 28.57		CDC4_YEAST (19-417): 2.5e-73: 247: 17.46
+	Hs
		1309163 TBL1R_HUMAN (251-570): 8.42e-66: 228: 18.58		TBL1Y_HUMAN (220-454): 1.04e-32: 131: 15.94
+	Sp
		144899 POP1_SCHPO (464-705): 1.48e-48: 184: 19.80		POP2_SCHPO (122-384): 1.02e-46: 173: 21.12
+	Sc
		759289 MET30_YEAST (447-706): 5.61e-59: 212: 25.24		MET30_YEAST (212-451): 1.99e-35: 140: 16.73
+	Sp
		144895 POP2_SCHPO (504-706): 2.04e-35: 145: 17.37		POP2_SCHPO (122-384): 1.02e-46: 173: 21.12
+	Hs
		792949 LIS1_HUMAN (457-706): 3.92e-66: 225: 27.08		WDR5_HUMAN (353-451): 3.15e-13: 72.5: 6.93
+	Hs
		209416 WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02		PLRG1_HUMAN (96-390): 6.55e-51: 181: 19.94
+	Sp
		953233 POP1_SCHPO (464-705): 1.48e-48: 184: 19.80		POP1_SCHPO (288-448): 2.07e-13: 74.5: 10.10
+	Sc
		630844 NLE1_YEAST (537-705): 1.06e-34: 140: 23.50		NLE1_YEAST (257-449): 8.84e-28: 117: 11.22
+	Hs
		903077 WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02		WDR5_HUMAN (353-451): 3.15e-13: 72.5: 6.93