HitPredict

Interactor 1: RNF34 (Q969K3)
E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF) (RING-type E3 ubiquitin transferase RNF34)
Gene: RNF34

Interactor 2: UBE2F (Q969M7)
NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)
Gene: UBE2F

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 185
+	Hs
		919809 RNF34_HUMAN (1-372): 3.26e-134: 389: 100.00		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		895865 RNF34_HUMAN (1-372): 3.26e-134: 389: 100.00		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		851859 RNF34_HUMAN (1-372): 3.26e-134: 389: 100.00		UB2E1_HUMAN (9-184): 5.43e-70: 212: 27.27
+	Hs
		849387 RFFL_HUMAN (8-372): 4.67e-111: 330: 42.78		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		919804 RFFL_HUMAN (8-372): 4.67e-111: 330: 42.78		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		895862 RFFL_HUMAN (8-372): 4.67e-111: 330: 42.78		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		849400 BIRC7_HUMAN (134-372): 2.95e-35: 132: 18.70		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		919817 BIRC7_HUMAN (134-372): 2.95e-35: 132: 18.70		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		895871 BIRC7_HUMAN (134-372): 2.95e-35: 132: 18.70		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		282581 RNF8_HUMAN (155-366): 3.49e-31: 125: 15.55		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		282607 RNF8_HUMAN (155-366): 3.49e-31: 125: 15.55		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		851864 BIRC7_HUMAN (134-372): 2.95e-35: 132: 18.70		UB2E1_HUMAN (9-184): 5.43e-70: 212: 27.27
+	Hs
		282595 RNF8_HUMAN (155-366): 3.49e-31: 125: 15.55		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		282716 RNF8_HUMAN (155-366): 3.49e-31: 125: 15.55		UB2E2_HUMAN (9-184): 1.68e-71: 216: 27.27
+	Hs
		282582 RNF8_HUMAN (155-366): 3.49e-31: 125: 15.55		UB2E1_HUMAN (9-184): 5.43e-70: 212: 27.27
+	Hs
		282705 RNF8_HUMAN (155-366): 3.49e-31: 125: 15.55		UB2E3_HUMAN (15-184): 2.12e-69: 211: 28.82
+	Hs
		849321 BIRC3_HUMAN (247-372): 2e-26: 112: 24.03		UB2D1_HUMAN (32-184): 8.75e-74: 220: 32.03
+	Hs
		919721 BIRC3_HUMAN (247-372): 2e-26: 112: 24.03		UB2D2_HUMAN (32-184): 5.23e-74: 220: 32.03
+	Hs
		895787 BIRC3_HUMAN (247-372): 2e-26: 112: 24.03		UB2D3_HUMAN (32-184): 2.78e-72: 216: 31.37
+	Hs
		896067 BIRC3_HUMAN (247-372): 2e-26: 112: 24.03		UBC12_HUMAN (15-176): 1.42e-33: 119: 39.51