HitPredict

Interactor 1: IF2B3 (O00425)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
Gene: IGF2BP3

Interactor 2: G3BP1 (Q13283)
Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)
Gene: G3BP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	26777405, 35031058
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 579 Hs			1 466
+	Hs
		1030522 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Hs
		128341 IF2B3_HUMAN (1-579): 2.3e-149: 444: 100.00		G3BP2_HUMAN (1-463): 4.59e-76: 248: 58.68
+	Hs
		1349171 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		G3BP2_HUMAN (1-463): 4.59e-76: 248: 58.68
+	Hs
		128256 IF2B3_HUMAN (1-579): 2.3e-149: 444: 100.00		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		1272119 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		311358 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		CELF2_HUMAN (318-402): 4.48e-12: 70: 17.78
+	Hs
		1030583 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Hs
		1030422 FUBP3_HUMAN (189-414): 5.52e-18: 89.3: 14.17		G3BP1_HUMAN (1-466): 1.13e-102: 316: 100.00
+	Hs
		1283866 FUBP1_HUMAN (353-559): 5.1e-29: 123: 23.22		G3BP2_HUMAN (1-463): 4.59e-76: 248: 58.68
+	Hs
		1357453 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		G3BP2_HUMAN (1-463): 4.59e-76: 248: 58.68
+	Hs
		1073540 FUBP1_HUMAN (353-559): 5.1e-29: 123: 23.22		SAFB1_HUMAN (93-439): 7.61e-35: 140: 12.39
+	Mm
		659498 PCBP1_MOUSE (277-508): 3.85e-32: 129: 24.14		CELF1_MOUSE (330-419): 1.64e-12: 71.2: 15.31
+	Hs
		1071950 PCBP1_HUMAN (277-508): 3.85e-32: 129: 24.14		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		311345 PCBP1_HUMAN (277-508): 3.85e-32: 129: 24.14		CELF2_HUMAN (318-402): 4.48e-12: 70: 17.78
+	Hs
		1071898 PCBP1_HUMAN (277-508): 3.85e-32: 129: 24.14		CELF3_HUMAN (335-423): 6.96e-12: 69.3: 17.90
+	Hs
		1272071 FUBP1_HUMAN (353-559): 5.1e-29: 123: 23.22		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		1072148 PCBP2_HUMAN (193-484): 7.41e-30: 122: 19.05		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		1272147 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		CELF1_HUMAN (330-419): 3.54e-12: 70: 14.29
+	Hs
		311359 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		CELF2_HUMAN (318-402): 4.48e-12: 70: 17.78
+	Hs
		311352 FUBP3_HUMAN (189-414): 5.52e-18: 89.3: 14.17		CELF2_HUMAN (318-402): 4.48e-12: 70: 17.78