HitPredict

Interactor 1: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Interactor 2: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 25241935, 26862156, 17426036, 21448668, 23695783, 29868881, 31125568, 23414517, 11243782, 21396940, 19240029, 15802564, 18795805, 22721718, 16338389
Identification Methods enzymatic study, pull down, two hybrid, x-ray crystallography, two hybrid fragment pooling approach
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains zf-B_box~zf-B_box, zf-B_box~zf-RING_UBOX, zf-RING_UBOX~zf-RING_UBOX
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005874 - microtubule
GO:0006936 - muscle contraction
GO:0007165 - signal transduction
and 12 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 353
Hs

1 353
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Last updated: 15 Jul 2024