HitPredict

Interactor 1: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	31391242
Identification Methods	two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 353 Hs			1 1437
+	Hs
		1317504 TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78		NSD3_HUMAN (1-1437): 0: 1169: 100.00
+	Hs
		1171583 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		NSD3_HUMAN (1-1437): 0: 1169: 100.00
+	Hs
		331832 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		1080208 TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		585025 RO52_HUMAN (8-353): 2.82e-75: 241: 14.74		EZH1_HUMAN (1076-1270): 4.39e-59: 220: 30.24
+	Hs
		584972 RO52_HUMAN (8-353): 2.82e-75: 241: 14.74		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1080304 TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1080310 TRIM4_HUMAN (15-347): 1.47e-66: 219: 17.27		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1317576 TRI31_HUMAN (8-301): 3.28e-59: 198: 21.77		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		855498 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		1282073 TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83
+	Hs
		1171280 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		1317542 TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83
+	Hs
		1080055 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		975275 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13