HitPredict

Interactor 1: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	31391242
Identification Methods	two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 353 Hs			1 859
+	Hs
		1290902 TRI11_HUMAN (8-353): 1.23e-72: 234: 17.63		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1317538 TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		585070 RO52_HUMAN (8-353): 2.82e-75: 241: 14.74		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		1318519 TRI31_HUMAN (8-301): 3.28e-59: 198: 21.77		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		585074 RO52_HUMAN (8-353): 2.82e-75: 241: 14.74		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		1172215 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		1172222 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		1171758 TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		1294945 TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37		PIWL1_HUMAN (23-826): 0: 751: 22.45