HitPredict

Interactor 1: LMBL2 (Q969R5)
Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)
Gene: L3MBTL2

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	27705803, 24981860, 33961781, 21596310, 28514442, 22325352
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Hs			1 350
+	Mm
		886508 LMBL2_MOUSE (1-705): 0: 1001: 90.92		PCGF6_MOUSE (41-350): 5.4e-85: 262: 92.90
+	Hs
		718083 LMBL2_HUMAN (1-705): 0: 1012: 100.00		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		718416 LMBL2_HUMAN (1-705): 0: 1012: 100.00		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		1108529 LMBL2_HUMAN (1-705): 0: 1012: 100.00		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Hs
		1282139 LMBL2_HUMAN (1-705): 0: 1012: 100.00		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		1197577 LMBL2_HUMAN (1-705): 0: 1012: 100.00		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Hs
		1282132 LMBL2_HUMAN (1-705): 0: 1012: 100.00		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Mm
		886509 LMBL2_MOUSE (1-705): 0: 1001: 90.92		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		988004 LMBL2_HUMAN (1-705): 0: 1012: 100.00		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Mm
		1160052 MBTD1_MOUSE (64-604): 0: 756: 61.14		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		718098 SCMH1_HUMAN (167-402): 7.35e-79: 267: 28.03		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		718330 SCML2_HUMAN (159-392): 8.81e-79: 267: 25.96		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		718418 SCMH1_HUMAN (167-402): 7.35e-79: 267: 28.03		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Hs
		1108531 SCMH1_HUMAN (167-402): 7.35e-79: 267: 28.03		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Hs
		1292153 SCMH1_HUMAN (167-402): 7.35e-79: 267: 28.03		PCGF1_HUMAN (119-347): 3.16e-60: 196: 34.91
+	Hs
		1197578 SCMH1_HUMAN (167-402): 7.35e-79: 267: 28.03		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Mm
		1225135 SCMH1_MOUSE (167-394): 1.83e-78: 267: 28.57		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		1292152 SCMH1_HUMAN (167-402): 7.35e-79: 267: 28.03		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		1304185 SCML2_HUMAN (159-392): 8.81e-79: 267: 25.96		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		988007 SCMH1_HUMAN (167-402): 7.35e-79: 267: 28.03		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96