HitPredict

Interactor 1: UB2E3 (Q969T4)
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)
Gene: UBE2E3

Interactor 2: TOPRS (Q9NS56)
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)
Gene: TOPORS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 207 Hs			1 1045
+	Hs
		1345306 UB2D4_HUMAN (61-206): 1.19e-82: 243: 63.01		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		919873 UB2D2_HUMAN (61-206): 2.03e-82: 242: 65.07		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		849457 UB2D1_HUMAN (61-206): 9.93e-82: 241: 61.64		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		895925 UB2D3_HUMAN (61-206): 1.1e-80: 238: 64.38		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		851891 UB2E1_HUMAN (35-207): 2.62e-79: 236: 87.36		TOPRS_HUMAN (1-1045): 0: 731: 100.00
+	Hs
		896550 UBE2N_HUMAN (59-206): 3.58e-69: 209: 45.27		TOPRS_HUMAN (1-1045): 0: 731: 100.00