HitPredict

Interactor 1: SPTSA (Q969W0)
Serine palmitoyltransferase small subunit A (Small subunit of serine palmitoyltransferase A) (ssSPTa)
Gene: SPTSSA

Interactor 2: SPTC3 (Q9NUV7)
Serine palmitoyltransferase 3 (EC 2.3.1.50) (Long chain base biosynthesis protein 2b) (LCB2b) (Long chain base biosynthesis protein 3) (LCB 3) (Serine-palmitoyl-CoA transferase 3) (SPT 3)
Gene: SPTLC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	19416851
Identification Methods	ubiquitin reconstruction, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Aminotran_1_2~SPT_ssu-like
Common GO terms	GO:0004758 - serine C-palmitoyltransferase activity GO:0005789 - endoplasmic reticulum membrane GO:0017059 - serine palmitoyltransferase complex GO:0030148 - sphingolipid biosynthetic process GO:0046512 - sphingosine biosynthetic process and 1 others more... GO:0046513 - ceramide biosynthetic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 71 Hs			1 552
+	Hs
		1244958 SPTSB_HUMAN (4-67): 4.27e-25: 90: 45.31		SPTC3_HUMAN (1-552): 0: 729: 100.00
+	Hs
		174227 SPTSB_HUMAN (4-67): 4.27e-25: 90: 45.31		SPTC2_HUMAN (6-549): 0: 677: 70.02
+	Hs
		174230 SPTSA_HUMAN (1-71): 1.12e-23: 86.2: 100.00		SPTC2_HUMAN (6-549): 0: 677: 70.02
+	Hs
		174114 SPTSB_HUMAN (4-67): 4.27e-25: 90: 45.31		SPTC1_HUMAN (55-529): 3.58e-145: 428: 23.72
+	Hs
		174124 SPTSA_HUMAN (1-71): 1.12e-23: 86.2: 100.00		SPTC1_HUMAN (55-529): 3.58e-145: 428: 23.72