HitPredict

Interactor 1: PMEPA (Q969W9)
Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein)
Gene: PMEPA1

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 287 Hs			1 975
+	Hs
		170561 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		808211 PMEPA_HUMAN (1-287): 0: 521: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Mm
		57497 A2APF4_MOUSE (5-287): 7.68e-160: 447: 88.69		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Mm
		808374 PMEPA_MOUSE (27-287): 3.8e-141: 399: 88.51		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Hs
		170566 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		170560 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		170532 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125004 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		170569 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		170568 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Hs
		170573 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84
+	Hs
		170549 LRAD4_HUMAN (32-285): 7.17e-131: 375: 65.88		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73