HitPredict

Interactor 1: IF2B3 (O00425)
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
Gene: IGF2BP3

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 35031058
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule GO:0051028 - mRNA transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 579 Hs			1 482
+	Hs
		1349171 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		128164 IF2B3_HUMAN (1-579): 2.3e-149: 444: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1030522 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		128256 IF2B3_HUMAN (1-579): 2.3e-149: 444: 100.00		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		1272119 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		311358 IF2B1_HUMAN (1-579): 1.24e-135: 408: 72.02		CELF2_HUMAN (309-419): 2e-14: 77.2: 18.10
+	Hs
		1283866 FUBP1_HUMAN (353-559): 5.1e-29: 123: 23.22		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		1357453 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		1030583 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1030422 FUBP3_HUMAN (189-414): 5.52e-18: 89.3: 14.17		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1073540 FUBP1_HUMAN (353-559): 5.1e-29: 123: 23.22		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		1071898 PCBP1_HUMAN (277-508): 3.85e-32: 129: 24.14		CELF3_HUMAN (326-416): 1.15e-15: 81.1: 21.28
+	Mm
		659498 PCBP1_MOUSE (277-508): 3.85e-32: 129: 24.14		CELF1_MOUSE (323-419): 3.4e-15: 79.6: 19.61
+	Hs
		1071950 PCBP1_HUMAN (277-508): 3.85e-32: 129: 24.14		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		311345 PCBP1_HUMAN (277-508): 3.85e-32: 129: 24.14		CELF2_HUMAN (309-419): 2e-14: 77.2: 18.10
+	Hs
		1272071 FUBP1_HUMAN (353-559): 5.1e-29: 123: 23.22		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		1072148 PCBP2_HUMAN (193-484): 7.41e-30: 122: 19.05		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		1272147 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		311359 IF2B2_HUMAN (79-477): 8.15e-20: 95.1: 15.50		CELF2_HUMAN (309-419): 2e-14: 77.2: 18.10
+	Hs
		311352 FUBP3_HUMAN (189-414): 5.52e-18: 89.3: 14.17		CELF2_HUMAN (309-419): 2e-14: 77.2: 18.10