HitPredict

Interactor 1: DNM1L (O00429)
Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)
Gene: DNM1L

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 0.60 0.698

The method score is based on:

Property Details
Experiments 30629163, 21292769, 35509820, 35256949
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, pull down, enzymatic study
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000266 - mitochondrial fission
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum
and 8 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 736
Hs

1 465
+ Hs
+ Hs
+ Sc
+ Hs
+ At
+ At
+ At
+ At
+ Zm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024