HitPredict

Interactor 1: VTI1A (Q96AJ9)
Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)
Gene: VTI1A

Interactor 2: VAMP8 (Q9BV40)
Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
Gene: VAMP8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	11101518
Identification Methods	affinity chromatography technology, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~V-SNARE_C
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005829 - cytosol GO:0031201 - SNARE complex GO:0031902 - late endosome membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 100
+	At
		221565 VTI11_ARATH (1-216): 4.44e-60: 189: 32.13		VA711_ARATH (1-98): 4.91e-30: 108: 27.55
+	Hs
		261703 VTI1A_HUMAN (1-217): 2.21e-63: 197: 100.00		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		1079397 VTI1A_HUMAN (1-217): 2.21e-63: 197: 100.00		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Rn
		1144366 VTI1A_RAT (1-217): 2.13e-60: 190: 93.30		VAMP1_RAT (6-85): 9.7e-27: 96.5: 33.75
+	Dm
		1178140 Q9W0N6_DROME (3-214): 2.01e-50: 165: 36.53		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Dm
		1178131 GOSR2_DROME (5-212): 3.58e-50: 164: 18.14		Q7JYX5_DROME (1-100): 8.7e-32: 112: 32.00
+	Mm
		291513 VTI1B_MOUSE (2-217): 4.1e-54: 174: 29.02		VAMP7_MOUSE (1-100): 3.19e-26: 98: 37.00
+	Dm
		577264 Q9W0N6_DROME (3-214): 2.01e-50: 165: 36.53		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Dm
		577252 GOSR2_DROME (5-212): 3.58e-50: 164: 18.14		SYB_DROME (5-95): 3.25e-30: 106: 27.47
+	Hs
		151535 GOSR2_HUMAN (5-212): 2.08e-53: 172: 14.09		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		850604 VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80		VAMP7_HUMAN (1-100): 1.25e-26: 99.2: 38.00
+	Hs
		261737 VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80		VAMP4_HUMAN (7-80): 3.4e-25: 93.4: 29.73
+	Hs
		1079465 VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80		VAMP3_HUMAN (7-79): 2.36e-24: 89.9: 36.99
+	Hs
		1313462 VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80		VAMP8_HUMAN (1-100): 2.94e-24: 89.6: 100.00
+	Sc
		704536 VTI1_YEAST (1-196): 6.08e-38: 132: 31.84		SNC2_YEAST (5-81): 2.16e-25: 93: 24.68
+	Sc
		979398 VTI1_YEAST (1-196): 6.08e-38: 132: 31.84		NYV1_YEAST (3-99): 2.82e-22: 88.4: 24.75