HitPredict

Interactor 1: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Interactor 2: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	25416956, 19549727
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 151 Hs			1 180
+	Hs
		1307272 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		RNF5_HUMAN (1-164): 8.79e-56: 175: 100.00
+	Hs
		849424 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RNF5_HUMAN (1-164): 8.79e-56: 175: 100.00
+	Hs
		1292368 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		849409 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		849406 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		TRI11_HUMAN (14-148): 2.69e-31: 119: 17.78
+	Hs
		849314 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		TRI26_HUMAN (14-123): 1.73e-28: 112: 21.85
+	Hs
		1318532 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		849437 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		1336390 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		849453 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		584907 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RO52_HUMAN (23-148): 9.12e-25: 101: 18.11
+	Hs
		1354526 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		TRI10_HUMAN (14-156): 5.89e-24: 99: 17.45
+	Hs
		849366 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		TRI22_HUMAN (20-126): 2e-24: 100: 19.64
+	Hs
		849475 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		TRI10_HUMAN (14-156): 5.89e-24: 99: 17.45
+	Hs
		262201 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		262161 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		849438 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		TRIM7_HUMAN (1-101): 4.17e-21: 91.3: 23.48
+	Hs
		849487 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		CBLC_HUMAN (6-93): 1.05e-19: 87.1: 28.28
+	Hs
		749252 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		BRCA1_HUMAN (25-76): 3.12e-19: 86.4: 34.62
+	Sc
		549834 UBC4_YEAST (1-150): 1.33e-68: 205: 32.00		PEX10_YEAST (26-68): 1.3e-14: 72.1: 41.86