HitPredict

Interactor 1: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Interactor 2: MARH5 (Q9NX47)
E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5)
Gene: MARCHF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	25416956, 32296183, 19549727, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 151 Hs			1 278
+	Hs
		849461 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		MARH5_HUMAN (1-278): 1.37e-162: 454: 100.00
+	Hs
		919880 UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33		MARH5_HUMAN (1-278): 1.37e-162: 454: 100.00
+	Hs
		895930 UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33		MARH5_HUMAN (1-278): 1.37e-162: 454: 100.00
+	Hs
		1282354 UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33		MARH5_HUMAN (1-278): 1.37e-162: 454: 100.00
+	Hs
		851894 UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00		MARH5_HUMAN (1-278): 1.37e-162: 454: 100.00
+	Hs
		1291149 Q96FI0_HUMAN (1-148): 1.13e-62: 191: 97.30		MARH5_HUMAN (1-278): 1.37e-162: 454: 100.00
+	Dm
		715100 UBE2N_DROME (1-150): 1.78e-62: 190: 27.33		Q9VB61_DROME (10-278): 9.68e-143: 404: 39.71