HitPredict

Interactor 1: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Interactor 2: RN115 (Q9Y4L5)
E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)
Gene: RNF115

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	33961781, 19690564
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0070979 - protein K11-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 151 Hs			1 304
+	Hs
		1377467 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		RN115_HUMAN (1-304): 2.11e-80: 247: 100.00
+	Hs
		849497 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RN115_HUMAN (1-304): 2.11e-80: 247: 100.00
+	Hs
		1313520 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		RN126_HUMAN (17-282): 5.46e-59: 192: 44.37
+	Hs
		849428 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RN126_HUMAN (17-282): 5.46e-59: 192: 44.37
+	Dm
		53092 A1Z8B5_DROME (2-150): 5.74e-70: 210: 71.14		IRU_DROME (12-301): 5.25e-50: 171: 26.25
+	Zm
		74334 B4FC97_MAIZE (4-150): 5.6e-69: 206: 32.65		B6U926_MAIZE (11-292): 2.99e-48: 167: 26.82
+	Zm
		79637 B6SZE0_MAIZE (4-150): 5.92e-69: 206: 31.97		B6U926_MAIZE (11-292): 2.99e-48: 167: 26.82
+	Hs
		196372 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		PJA2_HUMAN (5-296): 1.59e-40: 151: 18.45
+	Hs
		196282 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		PJA2_HUMAN (5-296): 1.59e-40: 151: 18.45
+	At
		715128 UBC8_ARATH (4-150): 2.84e-69: 207: 32.65		CIP8_ARATH (7-283): 6.56e-41: 146: 19.43
+	Hs
		849382 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RN128_HUMAN (49-301): 6.53e-39: 143: 21.53
+	Hs
		1356934 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		RN150_HUMAN (87-297): 5.62e-33: 127: 15.95
+	Hs
		849485 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RN150_HUMAN (87-297): 5.62e-33: 127: 15.95
+	Hs
		849491 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RNF6_HUMAN (55-276): 3.65e-31: 124: 20.89
+	Hs
		1204871 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		GOLI_HUMAN (58-298): 4.27e-29: 116: 15.95
+	Hs
		1327690 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		RNF38_HUMAN (85-271): 1.54e-28: 116: 23.40
+	Hs
		1349753 UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37		RN181_HUMAN (192-294): 1.74e-31: 116: 34.58
+	Hs
		849359 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		GOLI_HUMAN (58-298): 4.27e-29: 116: 15.95
+	Hs
		849443 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RNF38_HUMAN (85-271): 1.54e-28: 116: 23.40
+	Hs
		849467 UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69		RN181_HUMAN (192-294): 1.74e-31: 116: 34.58