HitPredict

Interactor 1: EXOS8 (Q96B26)
Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)
Gene: EXOSC8

Interactor 2: EXOS8 (Q96B26)
Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)
Gene: EXOSC8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.900

The method score is based on:

Property Details
Experiments 25416956, 32296183, 15231747, unassigned1304
Identification Methods two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains RNase_PH~RNase_PH, RNase_PH~RNase_PH_C, RNase_PH_C~RNase_PH_C
Common GO terms GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001650 - fibrillar center
and 18 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 276
Hs

1 276
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+ At
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+ Dm
+ Sp
+ Dm
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+ Sp

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Last updated: 15 Jul 2024