HitPredict

Interactor 1: ARRD3 (Q96B67)
Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)
Gene: ARRDC3

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.727

Property	Details
Experiments	28514442, 29416926, 33961781, 38270169, 23236378
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 414 Hs			1 903
+	Hs
		1252807 ARRD2_HUMAN (1-411): 3.62e-128: 377: 53.16		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1241904 ARRD4_HUMAN (4-411): 1.8e-123: 365: 51.10		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1285070 ARRD3_HUMAN (1-414): 2.2e-149: 431: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		1294858 TXNIP_HUMAN (1-399): 5.09e-112: 335: 40.75		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125633 ARRD3_HUMAN (1-414): 2.2e-149: 431: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1252814 ARRD2_HUMAN (1-411): 3.62e-128: 377: 53.16		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		1241917 ARRD4_HUMAN (4-411): 1.8e-123: 365: 51.10		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125595 ARRD2_HUMAN (1-411): 3.62e-128: 377: 53.16		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1285052 ARRD3_HUMAN (1-414): 2.2e-149: 431: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		125586 ARRD4_HUMAN (4-411): 1.8e-123: 365: 51.10		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		125707 TXNIP_HUMAN (1-399): 5.09e-112: 335: 40.75		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1252808 ARRD2_HUMAN (1-411): 3.62e-128: 377: 53.16		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		1241907 ARRD4_HUMAN (4-411): 1.8e-123: 365: 51.10		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		808216 ARRD3_HUMAN (1-414): 2.2e-149: 431: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1299631 TXNIP_HUMAN (1-399): 5.09e-112: 335: 40.75		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		1192131 ARRD2_HUMAN (1-411): 3.62e-128: 377: 53.16		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1192130 ARRD4_HUMAN (4-411): 1.8e-123: 365: 51.10		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1192211 TXNIP_HUMAN (1-399): 5.09e-112: 335: 40.75		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1285085 ARRD3_HUMAN (1-414): 2.2e-149: 431: 100.00		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34
+	Hs
		1252817 ARRD2_HUMAN (1-411): 3.62e-128: 377: 53.16		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34