HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: SHLB2 (Q9NR46)
Endophilin-B2 (SH3 domain-containing GRB2-like protein B2)
Gene: SH3GLB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	11894096, 11894095
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH3_9~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 395
+	Hs
		1285230 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SHLB1_HUMAN (1-395): 2.1e-79: 250: 59.24
+	Hs
		1285181 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH3G3_HUMAN (9-394): 6.12e-74: 235: 21.63
+	Hs
		1285180 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH3G2_HUMAN (9-394): 9.53e-72: 230: 22.14
+	Hs
		1285179 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH3G1_HUMAN (9-394): 8.12e-65: 213: 22.25
+	Mm
		1143925 SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59		SH3G2_MOUSE (9-394): 5.37e-71: 228: 22.14
+	Hs
		1089305 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG44_HUMAN (12-361): 4.87e-47: 173: 18.23
+	Hs
		1307444 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		SH3G2_HUMAN (9-394): 9.53e-72: 230: 22.14
+	Hs
		1285232 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		3BP1_HUMAN (15-353): 9.13e-41: 155: 15.39
+	Hs
		1148382 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG17_HUMAN (12-361): 1.74e-38: 149: 16.52
+	Hs
		1089312 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RHG44_HUMAN (12-361): 4.87e-47: 173: 18.23
+	Hs
		1377711 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		3BP1_HUMAN (15-353): 9.13e-41: 155: 15.39
+	Hs
		1148393 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RHG17_HUMAN (12-361): 1.74e-38: 149: 16.52
+	Hs
		1126372 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH319_HUMAN (338-394): 5.27e-13: 72.6: 38.60
+	Hs
		1078886 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		ITSN1_HUMAN (295-395): 2.46e-10: 64.7: 21.78
+	Mm
		1141132 GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91		PLCG1_MOUSE (22-394): 1.75e-38: 149: 11.81
+	Rn
		499159 GRB2_RAT (2-158): 6.97e-33: 128: 19.91		PLCG1_RAT (22-394): 1.99e-38: 149: 11.81
+	Hs
		580972 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		PLCG1_HUMAN (22-394): 6.24e-38: 147: 11.55
+	Mm
		1141129 GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91		VAV2_MOUSE (177-392): 1.51e-35: 140: 22.27
+	Hs
		1191849 SH3R2_HUMAN (1-597): 1.19e-43: 169: 16.35		SH3R1_HUMAN (296-394): 6.2e-15: 78.8: 18.18
+	Mm
		1141153 GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91		SH3K1_MOUSE (309-394): 1.09e-12: 71.5: 22.73