HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: ITSN2 (Q9NZM3)
Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Gene: ITSN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	22558309
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RhoGEF~SH3_9, SH3_2~SH3_9, SH3_9~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 1697
+	Hs
		1078886 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		ITSN1_HUMAN (2-1693): 0: 863: 56.23
+	Hs
		1126372 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH319_HUMAN (1035-1211): 6.54e-11: 69.3: 28.26
+	Ce
		1115108 Q6A573_CAEEL (76-628): 3.06e-42: 162: 21.83		VAV_CAEEL (1141-1621): 1.34e-70: 260: 16.44
+	Hs
		957984 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		FGD1_HUMAN (951-1604): 8.6e-65: 242: 14.05
+	Hs
		81660 B7Z9C6_HUMAN (1-631): 1.83e-45: 176: 14.72		FGD1_HUMAN (951-1604): 8.6e-65: 242: 14.05
+	Hs
		557629 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Hs
		787889 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		EPS15_HUMAN (7-478): 5.01e-32: 138: 16.98
+	Ce
		1149480 Q6A573_CAEEL (76-628): 3.06e-42: 162: 21.83		Q9U2T9_CAEEL (666-1214): 4.67e-17: 89.9: 13.17
+	Hs
		167066 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		ARHGB_HUMAN (1207-1441): 1.17e-20: 101: 30.08
+	Hs
		167080 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		ARHGB_HUMAN (1207-1441): 1.17e-20: 101: 30.08
+	Hs
		69770 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		B1ALK7_HUMAN (893-1003): 4.72e-14: 79.5: 22.32
+	Hs
		924777 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		Q96D37_HUMAN (526-1189): 9.13e-14: 78.7: 13.15
+	Hs
		548677 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		VAV_HUMAN (526-1189): 1.23e-13: 78.3: 13.15
+	Hs
		557687 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Hs
		557698 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		ARHG6_HUMAN (878-973): 2.21e-11: 71: 23.71
+	Hs
		924563 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		ARHG7_HUMAN (770-1003): 4.21e-12: 73.3: 18.14
+	Mm
		654982 GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91		VAV_MOUSE (526-1189): 6.47e-12: 72.9: 12.87
+	Hs
		855781 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		VAV2_HUMAN (614-1182): 8.45e-12: 72.6: 12.07
+	Mm
		1141129 GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91		VAV2_MOUSE (614-1182): 1.63e-11: 71.4: 13.29
+	Hs
		924617 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		SH319_HUMAN (1035-1211): 6.54e-11: 69.3: 28.26