HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	12829691, 34079125
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_2~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 665 Hs			1 1190
+	Hs
		1354510 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1167833 DNMBP_HUMAN (104-607): 3.03e-16: 85.1: 15.82		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		209185 NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1126376 SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Mm
		1143451 SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		1232491 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Hs
		990871 DNMBP_HUMAN (104-607): 3.03e-16: 85.1: 15.82		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		990858 SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		159209 ARHG7_HUMAN (228-354): 4.83e-14: 77.8: 20.31		CSKP_HUMAN (229-890): 6.3e-93: 321: 15.09
+	Hs
		924466 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		1141133 GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		223014 NCK2_MOUSE (184-428): 6.56e-15: 78.9: 12.41		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143326 SRBS1_MOUSE (3-155): 1.1e-13: 77: 34.15		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1113245 SRBS2_MOUSE (3-155): 3.32e-11: 68.9: 30.86		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143413 SH3R3_MOUSE (115-627): 5.78e-09: 61.6: 11.49		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		557746 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		235554 VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77