HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: 3BP1 (Q9Y3L3)
SH3 domain-binding protein 1
Gene: SH3BP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	32203420, 28514442, 31980649, 33961781, unassigned2213, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007015 - actin filament organization GO:0016477 - cell migration GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 701
+	Hs
		1089305 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG44_HUMAN (2-687): 3.58e-117: 372: 37.75
+	Hs
		1148382 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG17_HUMAN (2-697): 1.18e-113: 364: 37.41
+	Hs
		1191674 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SRGP1_HUMAN (3-674): 2.13e-106: 350: 15.79
+	Hs
		1377711 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		3BP1_HUMAN (1-701): 2.95e-126: 392: 100.00
+	Hs
		1089312 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RHG44_HUMAN (2-687): 3.58e-117: 372: 37.75
+	Hs
		1148393 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RHG17_HUMAN (2-697): 1.18e-113: 364: 37.41
+	Hs
		1172836 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG27_HUMAN (140-472): 3.53e-69: 245: 19.69
+	Hs
		1285187 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RGAP1_HUMAN (2-562): 2.13e-69: 240: 16.93
+	Hs
		1327819 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RGAP1_HUMAN (2-562): 2.13e-69: 240: 16.93
+	Hs
		200212 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		SRGP3_HUMAN (3-699): 9.93e-108: 354: 15.93
+	Hs
		253361 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		SRGP2_HUMAN (3-678): 7.22e-89: 302: 14.52
+	Dm
		1368053 Q9VIN1_DROME (2-656): 1.03e-49: 186: 16.50		RHGF_DROME (49-701): 2.32e-74: 261: 16.20
+	Hs
		64651 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		RHG32_HUMAN (261-689): 1.25e-75: 267: 22.20
+	Hs
		557642 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		CHIO_HUMAN (68-469): 1.36e-80: 266: 19.57
+	Hs
		64687 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		RHG32_HUMAN (261-689): 1.25e-75: 267: 22.20
+	Hs
		551038 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		CHIN_HUMAN (29-469): 1.17e-76: 255: 19.03
+	Hs
		557714 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		RHG21_HUMAN (107-701): 2.6e-66: 240: 14.98
+	Mm
		1141138 GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91		BCR_MOUSE (273-438): 3.07e-19: 95.1: 34.52
+	Hs
		506565 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		BCR_HUMAN (273-438): 1.05e-18: 93.2: 34.52
+	Hs
		69699 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		B1AHC3_HUMAN (274-436): 3.46e-17: 87.4: 33.94