HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	28514442, 31980649, 31142511, 33961781, 20457601, 17606992, unassigned1973, unassigned2173
Identification Methods	affinity chromatography technology, two hybrid fragment pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH3_9~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0007015 - actin filament organization GO:0016477 - cell migration and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 639
+	Hs
		1378080 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		1126957 Q5JPT6_HUMAN (1-665): 8.63e-127: 391: 100.00		Q5JPT6_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		1285167 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Mm
		1337544 CD2AP_MOUSE (1-663): 7.79e-83: 276: 31.53		CD2AP_MOUSE (1-639): 1.55e-120: 373: 85.60
+	Hs
		1191674 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SRGP1_HUMAN (2-455): 4.74e-38: 153: 13.51
+	Hs
		924773 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1141153 SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		1167820 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		51074 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SPD2B_HUMAN (3-589): 1.72e-16: 85.7: 11.64
+	Hs
		924988 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		1285205 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		1078886 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		1126372 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Mm
		1141167 CD2AP_MOUSE (1-663): 7.79e-83: 276: 31.53		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		253361 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		SRGP2_HUMAN (2-443): 3.56e-43: 169: 11.52
+	Hs
		208989 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		924630 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		1136530 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		SH3R3_HUMAN (5-625): 1.58e-17: 88.8: 13.36
+	Ce
		1149480 Q6A573_CAEEL (76-628): 3.06e-42: 162: 21.83		Q9U2T9_CAEEL (27-492): 3.56e-11: 68.5: 13.89
+	Hs
		51054 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		SPD2B_HUMAN (3-589): 1.72e-16: 85.7: 11.64