HitPredict - High confidence protein-protein interactions

Interactor 1: APH1A (Q96BI3)
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)
Gene: APH1A

Interactor 2: PEN2 (Q9NZ42)
Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)
Gene: PSENEN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.740

Property	Details
Experiments	22074918, 14572442, 19376115, 17911105, 18667537, 12740439, 15474363
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 17 others more... GO:0006509 - membrane protein ectodomain proteolysis GO:0007219 - Notch signaling pathway GO:0007220 - Notch receptor processing GO:0010008 - endosome membrane GO:0010950 - positive regulation of endopeptidase activity GO:0016020 - membrane GO:0016485 - protein processing GO:0019899 - enzyme binding GO:0031293 - membrane protein intracellular domain proteolysis GO:0032580 - Golgi cisterna membrane GO:0034205 - amyloid-beta formation GO:0042734 - presynaptic membrane GO:0042982 - amyloid precursor protein metabolic process GO:0042987 - amyloid precursor protein catabolic process GO:0043085 - positive regulation of catalytic activity GO:0061133 - endopeptidase activator activity GO:0070765 - gamma-secretase complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	265
Hs

1	101

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024