HitPredict

Interactor 1: SGK3 (Q96BR1)
Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like)
Gene: SGK3

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23589291
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0015459 - potassium channel regulator activity GO:0017080 - sodium channel regulator activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 496 Hs			1 975
+	Hs
		1299664 AKT3_HUMAN (20-493): 9.6e-167: 481: 38.27		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		681988 AKT1_HUMAN (20-491): 1.46e-165: 478: 36.48		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		117024 SGK1_HUMAN (86-495): 2e-162: 468: 66.34		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Mm
		1208292 SGK1_MOUSE (86-495): 8.33e-161: 464: 66.34		NED4L_MOUSE (17-975): 0: 1014: 98.02
+	Hs
		1299638 SGK2_HUMAN (129-495): 2.69e-152: 440: 66.76		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Xl
		1151478 SGK1A_XENLA (86-495): 3.32e-161: 465: 64.88		Q6GMD5_XENLA (7-975): 0: 1003: 89.69
+	Hs
		1299657 KS6B2_HUMAN (122-491): 2.13e-147: 432: 41.87		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Mm
		93288 SGK1_MOUSE (86-495): 8.33e-161: 464: 66.34		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Hs
		1285838 SGK3_HUMAN (1-496): 0: 548: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808324 AKT3_HUMAN (20-493): 9.6e-167: 481: 38.27		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		681731 AKT1_HUMAN (20-491): 1.46e-165: 478: 36.48		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		116984 SGK1_HUMAN (86-495): 2e-162: 468: 66.34		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808277 SGK2_HUMAN (129-495): 2.69e-152: 440: 66.76		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		616684 KS6B1_HUMAN (78-491): 3.96e-148: 435: 38.33		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808054 KS6A3_HUMAN (48-466): 8.02e-109: 341: 23.72		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		784035 KPCI_HUMAN (14-490): 3.77e-147: 435: 32.72		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		983863 KPCZ_HUMAN (161-458): 1.09e-90: 290: 45.60		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		566484 KPCA_HUMAN (42-490): 3.95e-147: 438: 33.55		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		784093 KPCI_HUMAN (14-490): 3.77e-147: 435: 32.72		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71