HitPredict

Interactor 1: ATG2B (Q96BY7)
Autophagy-related protein 2 homolog B
Gene: ATG2B

Interactor 2: WIPI4 (Q9Y484)
WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)
Gene: WDR45

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	28514442, 33961781, 35271311, 20562859
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000045 - autophagosome assembly GO:0000407 - phagophore assembly site GO:0032266 - phosphatidylinositol-3-phosphate binding GO:0034045 - phagophore assembly site membrane GO:0061723 - glycophagy
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2078 Hs			1 360
+	Hs
		1286041 ATG2B_HUMAN (1-2078): 0: 2754: 100.00		WIPI2_HUMAN (7-357): 3.21e-89: 277: 20.77
+	Hs
		1129423 ATG2B_HUMAN (1-2078): 0: 2754: 100.00		WIPI1_HUMAN (5-352): 3.85e-82: 258: 24.05
+	Hs
		1240446 ATG2B_HUMAN (1-2078): 0: 2754: 100.00		POC1A_HUMAN (3-172): 1.32e-28: 116: 10.92
+	Hs
		1103106 ATG2A_HUMAN (3-2074): 0: 2195: 41.32		WIPI4_HUMAN (1-360): 2.86e-93: 284: 100.00
+	Hs
		1103040 ATG2A_HUMAN (3-2074): 0: 2195: 41.32		WIPI1_HUMAN (5-352): 3.85e-82: 258: 24.05
+	Dm
		1373594 Q9VZX7_DROME (1-2075): 0: 1787: 26.07		Q9VSF0_DROME (7-352): 9.95e-80: 250: 22.58
+	Dm
		1367877 Q9VZX7_DROME (1-2075): 0: 1787: 26.07		Q9VIE1_DROME (12-328): 8.47e-67: 220: 22.01
+	Hs
		47695 A0AUL9_HUMAN (3-472): 5.57e-112: 368: 39.45		WIPI4_HUMAN (1-360): 2.86e-93: 284: 100.00
+	Sc
		837168 ATG2_YEAST (1806-2074): 4.82e-74: 276: 24.32		HSV2_YEAST (1-302): 2.8e-63: 209: 31.49
+	Sc
		797792 ATG2_YEAST (1806-2074): 4.82e-74: 276: 24.32		ATG18_YEAST (3-311): 1.54e-56: 193: 22.96