HitPredict

Interactor 1: DNM1L (O00429)
Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)
Gene: DNM1L

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31723608
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 736 Hs			1 577
+	Hs
		840787 DYN2_HUMAN (1-735): 0: 810: 38.29		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		128473 DNM1L_HUMAN (1-736): 0: 902: 100.00		MYH11_HUMAN (263-576): 6.07e-11: 67.9: 15.36
+	Hs
		983379 DYN1_HUMAN (1-735): 0: 825: 38.64		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		840702 DYN2_HUMAN (1-735): 0: 810: 38.29		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		840691 DYN2_HUMAN (1-735): 0: 810: 38.29		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Rn
		599413 DYN1_RAT (1-735): 0: 819: 38.90		ITSN1_RAT (38-416): 1.68e-18: 92: 13.13
+	Mm
		760469 DYN1_MOUSE (1-735): 0: 827: 38.77		ITSN1_MOUSE (1-363): 2.07e-11: 69.3: 12.09
+	Mm
		760488 DYN2_MOUSE (1-735): 0: 812: 38.16		ITSN1_MOUSE (1-363): 2.07e-11: 69.3: 12.09