HitPredict

Interactor 1: DHX58 (Q96C10)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
Gene: DHX58

Interactor 2: STAU2 (Q9NUL3)
Double-stranded RNA-binding protein Staufen homolog 2
Gene: STAU2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	21903422
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Helicase_C~dsrm
Common GO terms	GO:0003725 - double-stranded RNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 678 Hs			1 570
+	Hs
		1346015 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		STAU2_HUMAN (1-570): 0: 555: 100.00
+	Hs
		322980 DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00		STAU1_HUMAN (6-395): 1.38e-29: 125: 17.33
+	Hs
		585524 DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00		E2AK2_HUMAN (10-212): 2.07e-26: 115: 21.46
+	Hs
		269869 IFIH1_HUMAN (1-674): 7.37e-119: 381: 40.39		PRKRA_HUMAN (2-273): 4.61e-41: 152: 18.69
+	Hs
		269593 RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89		PRKRA_HUMAN (2-273): 4.61e-41: 152: 18.69
+	At
		1352640 DCL1_ARATH (2-509): 2.76e-91: 313: 24.56		DCL1_ARATH (73-375): 2.9e-42: 165: 19.75
+	Hs
		269939 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		PRKRA_HUMAN (2-273): 4.61e-41: 152: 18.69
+	Mm
		956560 DICER_MOUSE (3-558): 4.58e-91: 312: 22.35		TRBP2_MOUSE (2-194): 3.59e-35: 137: 20.83
+	Hs
		321872 RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89		E2AK2_HUMAN (10-212): 2.07e-26: 115: 21.46
+	At
		1352485 DCL1_ARATH (2-509): 2.76e-91: 313: 24.56		DRB2_ARATH (208-392): 1.2e-32: 131: 21.16
+	Hs
		323319 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		STAU1_HUMAN (6-395): 1.38e-29: 125: 17.33
+	Hs
		585588 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		E2AK2_HUMAN (10-212): 2.07e-26: 115: 21.46
+	Mm
		1163228 RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88		ILF3_MOUSE (274-428): 7.05e-13: 73.5: 21.38
+	Hs
		877391 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		DSRAD_HUMAN (6-184): 4.38e-18: 90.4: 19.47
+	At
		1209866 DCL1_ARATH (2-509): 2.76e-91: 313: 24.56		DRB5_ARATH (121-291): 1.75e-16: 83.5: 18.97
+	Hs
		1075651 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		TRBP2_HUMAN (294-466): 8.5e-16: 81.2: 15.64
+	Hs
		1020005 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		ILF3_HUMAN (274-428): 1.06e-11: 70: 21.38
+	Hs
		1302246 DICER_HUMAN (3-515): 7.66e-90: 309: 21.54		STRBP_HUMAN (178-374): 1.87e-11: 68.9: 19.70
+	At
		1108228 DCL2_ARATH (3-496): 9.09e-85: 293: 22.22		DRB5_ARATH (121-291): 1.75e-16: 83.5: 18.97
+	At
		952787 DCL4_ARATH (3-522): 1.66e-86: 299: 21.68		DRB4_ARATH (12-215): 2.21e-09: 61.5: 17.79