HitPredict

Interactor 1: DNM1L (O00429)
Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)
Gene: DNM1L

Interactor 2: FIS1 (Q9Y3D6)
Mitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11)
Gene: FIS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

The method score is based on:

Property	Details
Experiments	12861026, 32877691, 37866629, 29464060
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000266 - mitochondrial fission GO:0001836 - release of cytochrome c from mitochondria GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005777 - peroxisome and 11 others more... GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0007005 - mitochondrion organization GO:0008289 - lipid binding GO:0010821 - regulation of mitochondrion organization GO:0016020 - membrane GO:0016559 - peroxisome fission GO:0032991 - protein-containing complex GO:0043653 - mitochondrial fragmentation involved in apoptotic process GO:0090141 - positive regulation of mitochondrial fission GO:2001244 - positive regulation of intrinsic apoptotic signaling pathway
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	736
Hs

1	152

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024