HitPredict

Interactor 1: FAF2 (Q96CS3)
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Gene: FAF2

Interactor 2: DERL2 (Q9GZP9)
Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)
Gene: DERL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	22119785, 26186194, 26389662, 28514442, 33961781, 21909096
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0030970 - retrograde protein transport, ER to cytosol GO:0036503 - ERAD pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 445 Hs			1 239
+	Hs
		1287162 FAF2_HUMAN (1-445): 1.33e-143: 419: 100.00		DERL1_HUMAN (6-238): 1.01e-70: 218: 34.15
+	Sc
		979140 UBX2_YEAST (9-430): 9.04e-66: 222: 16.38		DFM1_YEAST (7-238): 2.29e-53: 177: 23.16
+	Hs
		1267601 UBXN4_HUMAN (268-442): 1.92e-23: 104: 17.05		DERL2_HUMAN (1-239): 7.87e-93: 274: 100.00
+	Sc
		748213 UBX2_YEAST (9-430): 9.04e-66: 222: 16.38		DER1_YEAST (13-212): 3.33e-45: 152: 21.29
+	Hs
		116707 UBXN8_HUMAN (260-443): 9.7e-35: 132: 17.94		DERL1_HUMAN (6-238): 1.01e-70: 218: 34.15
+	Sc
		748979 UBX7_YEAST (154-445): 4.26e-48: 172: 10.60		DFM1_YEAST (7-238): 2.29e-53: 177: 23.16
+	Hs
		1267598 UBXN4_HUMAN (268-442): 1.92e-23: 104: 17.05		DERL1_HUMAN (6-238): 1.01e-70: 218: 34.15