HitPredict

Interactor 1: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 25416956, 25910212, 26871637, 29394115, 30327196, 32296183, 31723608, 23414517, 33545068, 20161783, 24983867, unassigned1304
Identification Methods two hybrid, pull down, affinity chromatography technology, proximity labelling technology, fluorescent resonance energy transfer, two hybrid array, anti tag coimmunoprecipitation, split luciferase complementation, two hybrid bait and prey pooling approach, validated two hybrid and 2 others

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Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CC2-LZ~CC2-LZ, NEMO~NEMO
Common GO terms GO:0000139 - Golgi membrane
GO:0001920 - negative regulation of receptor recycling
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 25 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 577
Hs

1 577
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Last updated: 15 Jul 2024