HitPredict

Interactor 1: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Interactor 2: MLP3C (Q9BXW4)
Microtubule-associated proteins 1A/1B light chain 3C (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (MAP1A/MAP1B light chain 3 C) (MAP1A/MAP1B LC3 C) (Microtubule-associated protein 1 light chain 3 gamma)
Gene: MAP1LC3C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	26451915, 37219487
Identification Methods	two hybrid, unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 147
+	Hs
		306267 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		GBRAP_HUMAN (13-127): 3.44e-54: 168: 38.26
+	Hs
		891267 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		GBRL2_HUMAN (13-126): 1.65e-54: 168: 42.98
+	Hs
		1287379 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		MLP3A_HUMAN (7-126): 2.49e-53: 165: 59.17
+	Hs
		1287372 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		MLP3B_HUMAN (7-127): 8.15e-53: 164: 54.55
+	Hs
		1287376 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		GBRL1_HUMAN (13-126): 4.75e-52: 162: 39.47
+	Mm
		1225237 OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80		MLP3A_MOUSE (7-126): 2.49e-53: 165: 59.17
+	Hs
		502871 LAMC1_HUMAN (59-543): 3.86e-30: 128: 13.64		MLP3B_HUMAN (7-127): 8.15e-53: 164: 54.55
+	Hs
		1051455 DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58		MLP3B_HUMAN (7-127): 8.15e-53: 164: 54.55
+	Hs
		305947 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRAP_HUMAN (13-127): 3.44e-54: 168: 38.26
+	Hs
		551651 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRL2_HUMAN (13-126): 1.65e-54: 168: 42.98
+	Hs
		551835 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		MLP3A_HUMAN (7-126): 2.49e-53: 165: 59.17
+	Hs
		551829 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		MLP3B_HUMAN (7-127): 8.15e-53: 164: 54.55
+	Hs
		551832 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRL1_HUMAN (13-126): 4.75e-52: 162: 39.47
+	Hs
		725011 MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08		GBRL1_HUMAN (13-126): 4.75e-52: 162: 39.47