Interactor 1: MEN1 (O00255)
Menin
Gene: MEN1

Interactor 2: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.71 0.55 0.628

The method score is based on:

Property Details
Experiments 35271311, 35850772, 32971831
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003682 - chromatin binding
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0010332 - response to gamma radiation
Homologous interactions 0

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Last updated: 11Aug2025