HitPredict

Interactor 1: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Interactor 2: MLP3B (Q9GZQ8)
Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)
Gene: MAP1LC3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.717

Property	Details
Experiments	30679426, 21617041, 23805866, 32296703, 25026213
Identification Methods	affinity chromatography technology, unspecified method, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome GO:0005829 - cytosol GO:0006914 - autophagy
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 125
+	Hs
		1287379 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		MLP3A_HUMAN (1-120): 8.21e-55: 168: 82.50
+	Hs
		891267 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		GBRL2_HUMAN (7-120): 2.21e-53: 165: 39.47
+	Hs
		306267 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		GBRAP_HUMAN (7-121): 6.4e-53: 163: 31.30
+	Hs
		1287366 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		MLP3C_HUMAN (1-120): 2.08e-51: 161: 55.00
+	Hs
		1287376 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46
+	Mm
		1225237 OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80		MLP3A_MOUSE (1-120): 8.21e-55: 168: 82.50
+	Hs
		502871 LAMC1_HUMAN (59-543): 3.86e-30: 128: 13.64		MLP3B_HUMAN (1-125): 8.28e-57: 173: 100.00
+	Hs
		1051455 DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58		MLP3B_HUMAN (1-125): 8.28e-57: 173: 100.00
+	Hs
		551829 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		MLP3B_HUMAN (1-125): 8.28e-57: 173: 100.00
+	Hs
		551835 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		MLP3A_HUMAN (1-120): 8.21e-55: 168: 82.50
+	Hs
		551651 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRL2_HUMAN (7-120): 2.21e-53: 165: 39.47
+	Hs
		305947 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRAP_HUMAN (7-121): 6.4e-53: 163: 31.30
+	Hs
		551832 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46
+	Hs
		725011 MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08		GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46