HitPredict

Interactor 1: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Interactor 2: GBRL1 (Q9H0R8)
Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
Gene: GABARAPL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	21617041, 31723608, 37219487
Identification Methods	pull down, proximity labelling technology, unspecified method, two hybrid, affinity chromatography technology, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 117
+	Hs
		891267 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		306267 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		1287366 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		MLP3C_HUMAN (5-116): 1.61e-44: 143: 39.47
+	Hs
		1287379 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		1287372 OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Mm
		1225237 OPTN_MOUSE (1-577): 1.53e-43: 165: 75.80		MLP3A_MOUSE (5-116): 1.09e-44: 142: 34.21
+	Hs
		502871 LAMC1_HUMAN (59-543): 3.86e-30: 128: 13.64		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		551651 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRL2_HUMAN (1-116): 1.39e-57: 175: 61.21
+	Hs
		1051455 DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62
+	Hs
		305947 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRAP_HUMAN (1-116): 2.96e-56: 171: 87.07
+	Hs
		551832 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		725011 MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08		GBRL1_HUMAN (1-117): 4.54e-56: 171: 100.00
+	Hs
		551835 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		MLP3A_HUMAN (5-116): 1.09e-44: 142: 34.21
+	Hs
		551829 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		MLP3B_HUMAN (2-116): 1.06e-43: 140: 31.62