HitPredict

Interactor 1: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Interactor 2: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	21408173, 25923723
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045087 - innate immune response GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 577 Hs			1 956
+	Hs
		1343420 NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		1051478 DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Mm
		291808 NEMO_MOUSE (204-576): 2.74e-40: 153: 25.33		CYLD_MOUSE (1-956): 0: 1825: 94.46
+	Hs
		551848 DESP_HUMAN (6-522): 2.58e-16: 85.1: 11.60		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		149325 CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		725251 MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		254517 ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22		CYLD_HUMAN (1-956): 0: 1872: 100.00
+	Hs
		725032 MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08		CYLD_HUMAN (1-956): 0: 1872: 100.00